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These ingredients can cause serious health problems. Some consumers reported experiencing chest pain, chills, diarrhea, dizziness/lightheadedness, fatigue, headache, high blood pressure, high heart rate, jitters, nausea, nervousness, rash, stomach pain or upset, sweating, and vomiting.
Hordenine can be unsafe when taken swallowed. It can cause rapid heart rate, elevated blood pressure, jitteriness, nausea, vomiting, and insomnia. Pregnant women and consumers with cardiovascular disease are more likely to experience these adverse events. Hordenine is not an approved ingredient in dietary supplements.
Octodrine or DMHA (1,5-Dimethylhexylamine) is similar to the stimulant dimethylamylamine (DMAA) which was removed from the market in certain countries for safety concerns. In animal studies, octodrine causes increased heart rate, myocardial contractility, and pain threshold. No date exists on its metabolic pathway in humans, so the use during exercise is potentially dangerous. DMHA does not meet the statutory definition of a dietary ingredient and is an unsafe food additive.
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